The problem with our four strikers is that they are all limited in some way or another.
Kean
Pros: young, fast, and a natural eye for goal
Cons: very raw, not particularly good ball control and looks down when dribbling
Higuain:
Pros: a very good finisher with both feet, links up with Cris
Cons: fat and slow as fuck, well past his prime
Dybala
Pros: technically gifted, exceptional finisher
Cons: one footed and slow, no threat in the air
Mandzukic:
Pros: Strong and tall, can head the ball well
Cons: a very average finisher and goalscorer for his position, past his prime
As it stands at the moment, I still see Dybala false9 as the best option.