The way I see our midfield is that it has a bunch of specialists who are WC or great at certain tasks like Pjanič, Matuidi, it also has some energetic younger players with a lot of experience already in their legs like Bentancur and Can and we also have some oldies who can provide experience and cover like Khedira and Marchisio, but the things these 6 players offer are so similar that it's hard to see them become a functional mid 3.
There's no one technically great enough like Pirlo who could receive the ball with 2 players on him and just deal with it or no one like Pogba who could break the press by bulldozing the ball forward. I don't think we'll have much problems against the small, brutal teams as Matuidi and Can probably love these type of games, but if we face a team with a good midfield like Spurs again, we'll have exactly the same problems as last year.