I reckon they'll cause us problems for an hour then tire, match sharpness will also surely play a part. Who knows what condition we will be in, but there will be a 12-day gap between Samp and Lyon.
I watched Rangers against Coventry on Saturday, and if Rangers can beat Lyon in a semi-competitive match we have more than a chance. They fell asleep twice against Rangers, and those are the kind of things that happen without sharpness.
Our lack of attacking depth is a concern, but Berna and DC tend to do better in the CL games with more open football.