Maybe it was mentioned already, but compare Conte's approach in serie A/ Europe, to Mourinho's approach in serie A and Europe when Inter won it.
Mourinho realized that what worked for him in serie A fails in Europe, so he even put Pandev and Eto'o on the wings of a 4-2-3-1. In Serie A he was using another system, but in Europe he chose an entirely different formation. He adapted. Conte couldn't adapt and he used Pepe's absence as an excuse.
I feel sorry for this Juve generation. Individually we have really strong players. But with Pirlo, Barzagli, Buffon, Vucinic, soon Chiellini, Licht, Tevez in their 30's, it's gonna take some other Juventus to do well in the CL and make the last stages. Last year things could be blamed on inexperience in the CL. That's why we were happy with the 1/4 finals. But this year we simply had to adapt to European football. Conte stubbornly refused to do so, both in the summer mercato and after it.