Personally I think his teams are so structured that they don't suit knock out football so well. Unless you are going to do something like Mourinho and a backs-to-the-walls defensive job against a superior set of players then these important one-off games are better suited to playing a more open and loose approach, less tactical rigidity but without losing your defensive shape, give players a bit more freedom.
League football is not like cup football, it's not just another 90 minutes because in cup football you often have to be bolder and risk more to earn more, in the league there is always another game in the minds of those players who are not forced to focus on each game like Conte's players are.