In the case of you guys getting two new fullbacks, then the 4-3-1-2 would suit your team indeed. Especially because you guys have a lot of central midfielders.
But if not, then i do believe players like Molinaro and Grygera would be way too exposed, and the team would be too predictable, as most play would go through the center due to the fullbacks not offering any attacking threat or width whatsoever.
As long as Molinaro and Grygera are starting for this team, i do not believe the 4-3-1-2 system would be applicable.