Forget starting Mandzukic and Zaza right now. One is not match fit and certainly should not be starting an important CL match, and the other is not starting caliber material at all.
Deploy our attackers in the 4-3-3, like he did in the two matches before the break. Cuads wide right, Dybala playing in the middle, Morata on the left... and then when play is in the final third it's very fluid, Morata drifting central, Paulo supporting but frequently drifting left. Defend as either a 4-4-2/4-5-1.