He always played with a lot of space behind him (youth and first team). Ajax plays with a very high line.
He doesn't has problem with pacey players. And he has played against Mbappe several times now.
He might look big, but he's far from slow. And his positional awareness is great. He also has a well timed tackle. So ya, he can neutralize pacey players.
BTW. He also scored on his debut at Ajax (when he was 17). So that's his trademark i guess.