Here's something...
Apparently the English are much better prepared physically than the Italians? What changed? I thought Italy did look tired in the groups but last night they played with swagger.
It's playing 4-3-1-2 that helps a lot, I think.
With 3-5-2 pretty much all the running had to be done by the midfield five.
With 4-3-1-2 the two fullbacks do their share so the bulk of the running is shared between six.
It's also a system that allows you to do more of the defending in midfield, in relatively safe areas, where 3-5-2 tends to require a lot more of the defending to be done from the defenders as it is tougher for the midfield to sheild them as well.
Also, Prandelli has started to make better changes as the tournament has gone on and brought on appropriate players at appropriate times against England.
As for England, it's just a really hard slog playing with everyone behind the ball the whole game. Particularly tough for the midfield two who were heavily outnumbered.