Prandelli should replace/rest those players who aren't vital to the team. I'm talking about the match vs Ireland. Italy are the much better team and should win it. So, lets say, rest 5-6 players on which Italy can count in the knock outs. Rest one of the attackers, play Balzaretti, Abate on the wings instead of Giac and Maggio, and play Nocerino in midfield. Since Pirlo is the team, it won't change a lot who plays next to him and in front of him when Italy faces Ireland, but a "not exhausted" Cassano, Marchisio, Maggio etc can make a difference in the quarters compared to a more tired squad.