Since we lack a very important factor in midfield, I don't think we should drop the back three as the personnel there is badly needed. May I suggest a 3-4-3?
Buffon
Barzagli Bonucci Chiellini
Dani Alves Khedira Pjanic Alex Sandro
Cuadrado Higuain Pjaca
Yes we sacrifice Dybala but he is totally out of form and one should not close an eye to that just because it's Dybala.
Dani Alves and Alex Sandro won't be as much of a threat forward with two wingers in front of them but we need them to support Khedira and Pjanic.
This formation also allows Bonucci to push a bit forward and do some regista work from time to time and since we have Higuain, we could supply him with lots of balls this way mostly from the flanks.
A temporary solution until the saviour returns from injury.