Give Sandro and one of Matuidi/Pjanic a rest.
Give Bentancur another 90 minutes playing time, it's needed there.
Same goes for Dybala being captain.
Play Perin.
Perin
De Sciglio Barzagli Benatia Cancelo
Bernaguti Pjanic Bentancur
Costa Dybala(c) Ronaldo
If Spazzolino already is ready, play him on the left and Cancelo on the right.