I'm not so concerned about Chiellini missing this one as others. He's a big game player but also a player who likes a direct battle. The sort of attackers Napoli have don't suit him at all, he'd be faced with smaller technical players. Barzagli can go up against Higuain, Bonucci in his usual role, and Rugani to the right. Lichtsteiner will surely play that side so offers cover. On the left Alex Sandro would balance the side up more, but Barzagli needs less cover than Rugani would against Insigne. Sturaro will probably play anyway to help negate that.
And we will have good bench options with Zaza, Pereyra and Cuadrado.