Maybe if Mourinho wakes up and decides to match Dortmund's pace.
Alonso, Khedira and Modric midfield was the biggest joke I've seen in the last few years in the CL. No Di Maria as well was a mistake unless he had some sort of injury.
Start with the usual 4 attackers: Ronaldo, Ozil, Di Maria, Benzema/Higuain.
Put Pepe at Right DM to break up Reus's countering channels, Ramos back to CB with Varane.
Dortmund will naturally concede some possession so the possession players like Modric and Alonso are probably not needed. Try to score initially on possession but don't be afraid to give up counters and then counter in return. That's why Pepe and maybe Essien could be useful at DM. Feed Ronaldo as much as possible.