In the current setup , you can already say Dybala's been replaced. Bernardeschi is more of a TQ/midfielder than Dybala will ever be and is good at creating chances/playing through passes that Higuain can latch onto. Basically he is a much better fit than Dybala in the current formation.
What would change ? Maybe the onus will be on Higuain to score a lot more goals than he has this season. Maybe he'll have a lot more chances to score with two creative players by his side who assist more than they score more.
What we would miss ? Dybala's individual brilliance. His ability to create something out of nothing. His finishing. Like I said, in his absence , Higuain would have take the burden of scoring a large majority of the goals especially since a major chunk of that money will be spent on sorting out the midfield as well. (Martial as first change sub)
There are ideal conditions to make the team perform better without Dybala and compensate for his individual brilliance. But we said the same about Pogba who's in pretty much the same boat as him and now we all wish we could have Pogba back.