The EPL is hyper competitive. It is physically demanding like no other league in the world, and there is more strength in depth than at any other point in time in any league. There are no super teams, like Bayern, Real or Barca. In their domestic leagues, Juve, the Spanish giants, Bayern, can win a very high percentage of their games at a canter. In the EPL you have to fight tooth and nail almost every week. It's crazy. The more competitive the league has become, the worse EPL teams have done in Europe. They are just coming into the midweek matches with their energy levels more depleted. And at the top level of sport, 5% can make a huge difference. It used to be that the EPL teams would rest players at the weekend with a big European match in mind, but it's just not the case anymore. If anything, it is vice versa. The EPL TV money dwarfs the UCL money. This is especially exaggerated once the team has already gotten participation money for the group phase, as incremental bonuses for reaching round of 16 and QF's aren't that big of a deal anymore.
I would even venture that the Premier League itself, won't lose much sleep over losing the 4th UCL slot. From a marketing standpoint it has much better worldwide coverage than the champions league.
With all of that said, with relation to Dybala. I actually wasn't saying it was better or worse, but that the pace is so different when you go to different leagues. He'd get chased, harried, bullied, and pressed so much more aggressively in England than he does in Italy. His technique looks masterful in that video, but from the perspective of a Manchester United fan, I think he'd find England a very different prospect. Some smaller technical players thrive here, some flop. There are very few examples of players coming from Serie A and being able to cope with the EPL. He'd probably fare better in Spain.