If Sturaro gets picked ahead of Marchisio I am confident it is down to Marchisio's fitness/form, and in that case it makes sense to pick Ruru. The midfielders in this game most liekly needs to combine more 35km. Perhaps too demanding a task for Marchisio currently.
Douglas Costa has played more than 60 games in Europa League and CL. Not only is he the better player between him and Berna, he is also more experienced and adds an individual touch than Berna stills lacks.
Obviously a performing Mandzu is key to succes against a hard working, high paced, and high pressing team such as Tottenham. His work rate and ability to hold on to the bold will be key to avoid the pressure from Spurs; add to that Mandzu's european experience.
All in all nothing outrages about the alleged starting lineup from Allegri. Trust in EuroMaxx, doubt Marotta's depth.