Don't think it would work better than the 4-2-3-1 they play now. I remember Ronaldo wasn't happy when he was played as striker with his NT, He prefer playing on the LW so he can cut inside.
i don't remember the last time i saw ronaldo cutting inside in a classico...sure he can do that with la liga jerk teams..he will have a bigger impact as a striker just as he played at manure when he used to score +40 in a season.