He should play as many new players as possible. I remember Alen saying after the Siena game that we should try not to use too many of the same players that played that game. So..
Manninger
Zebina - Legro - Chiellini - Grosso
Sissoko - Marchisio
Candreva - Diego - Giovinco
Iaquinta
Only Diego, Sissoko, Zebina and Grosso where there when we fucked up against Fulham, the rest wasn't there.
I mean surely it wouldn't harm us to play Manninger, Chiellini, Giovinco and Iaquinta even if they just came back from injury, after all, the team is not doing that good anyhow.