If someone is to be rested from the start, it's Marchisio, but he never stops running so I don't know.
Agree with anyone saying that only one of MVP should be rested, if needed to.
You know with Marchisio that he'll run himself into a slump, he has done it in basically every season he has been established in the team. At least now we have viable alternatives.
I still see Marrone as his alternative, or putting Pogba in or Asamoah inside with De Ceglie LWB are options.
Personally I think this is a game where we will be tempted to rotate, we've got three tough games bunched together after this:
Sat 22/09/12 SEA Juventus 19 : 45 Chievo
Tue 25/09/12 SEA Fiorentina 19 : 45 Juventus
Sat 29/09/12 SEA Juventus 19 : 45 Roma
Tue 02/10/12 UCL Juventus 19 : 45 Shakhtar Donetsk
I'd expect to see Pogba or Marrone start this game.