We are playing Chelsea 3 days later - that is a make or break match for our whole season in a way. I would definately rest a lot of players against Lazio. Pirlo is suspended which is a blessing in disguise because he has rarely had a break this season.
Perhaps I would go for: Buffon, Caceres, Bonucci, Barzagli, Isla, Giaccherini, Pogba, Vidal, Matri, Bentdner
I would rest: Chiellini, Vidal or Marchisio (have one sub the other at half time), Quags, Giovinco and Vucinic. Pirlo rested due to suspension.
If we lose points against Lazio, I can live with that given we are 4 points ahead in the table and have the match of the season against Chelsea 3 days later. That is a must win game against the European Champions!