This is actually a game I see there being a chance of Juve losing.
Players are never at their best coming off international breaks and when you add in the game against Chelsea in midweek, there is a distinct danger of Juve not being as focused on this game as they ought to be.
4-3-3 is also a system that 3-5-2 is not well suited to playing against.
You tend to either end up playing three versus three at the back, or the wingbacks get dragged back to help ought and the 3-5-2 team struggles for width high up the pitch.
Not an insurmountable problem, but not easy to get the balance right between defensive solidity and still playing your own attacking game.
Could Giaccherini be preferred at LWB over De Ceglie because that would allow the team to change to 4-3-3 very easily, in case there are issues playing 3-5-2 against 4-3-3?