I think he should consider resting Khedira again.
He relies heavily on his stamina, and I don't think it's a coincidence his form dropped recently.
Also, he'll play for Germany again and it's always a gamble to make him play so many times in a row.
Empoli is now a weak team, and Lemina can do a lot of damage if playin as a RCM, his most suited position.
I'd rest him this game.
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And maybe Alves could use a break too. He'll play as a starter for Brazil in 2 tough games.
I'd unleash Lemina + Cuadrado on the right, it could work very well.