Pogba is exhausted, the guy played virtually every game this season. His decline in performance is no coincidence.
Marchisio is the same. When he gets tired, his game goes downhill.
For this game, I'd rest one between Bonucci and Barzagli; both Marchisio and Pogba; and probably Mandzukic.
I'd go with Lemina for Marchisio, Cuadrado as a CM for Pogba.
Buffon - Licht, Bonucci, Rugani, Alex Sandro; Lemina, Cuadrado, Khedira, Pereyra; Dybala, Morata.