If a Juve team at home that will consists of the likes of Hernanes, Cuadrado, Pereyra, Zaza, Sturaro, Evra, Caceres, Rugani, et al can't beat Genoa at home, then I don't know what to say. Pereyra is going to HAVE to play sometime, so why not in midweek?
And to me, this would be the perfect time to make these types of changes, because then this club can play at full strength at Frosinone and then home to Napoli, with the proper rest cycle for the starters between those two matches. In my opinion, the more bench players that you can put onto the field on Wednesday, the better.
Napoli cannot afford to do this on Wednesday. They are away to Lazio. Even though they have Carpi at home the following week, their rotation schedule could get messed up.