Look, you're using Giovinco as a striker in a system where crossing into the box is a major part of play. Much of the time he has to hold the ball up under pressure in the middle of the pitch in the attacking third as the wing backs are back defending. There's no attacking midfielder. It's not a system suited for him at all.
He should probably do better as he squanders too many chances. But as anyone can see, Seba would be better suited for the 433. And please don't tell me the system doesn't matter when we play Asamoah on the flank, which is no different than clown Del Neri using Marchisio out there.