Play him as holding mid in a 4231, with Cuadrado and Pjanic next to him, Dybala in front of him, and he can keep it simple. Quick short passes, running into channels and supporting the attack every now and then, similar to his role in the german NT (and back then at Real Madrid) with Kroos next to him.
Play him RCM in a 4312, and he has to boss the entire right pretty much on his own, even worse with alves injured.
I'd say let's stick to the oldschool 1 creative 1 holding mid system, at least until we sign a player like Tolisso.