Perhaps we could play something like this:
Ronaldo - Dybala
Pjanic
Rabiot - Bentancur - Ramsey
1. Pjanic can play the luxury role of trequartista, which does not require as much defensive effort. This is the same role he played in his final season at Roma.
2. Ramsey and Rabiot both have the legs to play B2B midfielders. In the likely event Ramsey gets injured, we could try Berna in that role.
3. Rodrigo plays as regista which in my opinion is his best position. He is strong defensively, a tidy passer, and can carry the ball forward.