There is a lot of steps you skipped over there. Sarri's CF is not about holding up the ball, it's about linking up as a whole. Mandzukic was the worst fit because he is by far worse than the other 2 at it. Remember when Dybala was injured for a long time and we played Higuain-Mandzukic where Higuain was playing as the second striker? Because he is the much better player at that.
Dybala is technically better of course but he doesn't play on the CBs like Higuain does, he cant do the hold up the ball part. Higuain is the happy medium between Dybala and Mandzukic.
Dybala can be the CF, it just requires a restructuring of the tactics to adapt to the different interpretation of the role.
Atletico game aside, Higuain has been one of our best players this season.