Khedira Marchisio Pjanic
Is closest to last seasons midfield. That could function quite well. It gets thin after that though. And it's frustrating: that midfield plus Pogba would've been so dominant.
I think we need a DM much more than a CM. I think Lemina and Asamoah can do the job to alternate with Khedira but we badly need a replacement for Marchisio. I'm not the biggest fan of playing Pjanic as regista, I like him better in Pogba's spot.
Khedira-Biglia or Gustavo-Pjanic in the mean time.
When Marchisio returns, Khedira-Marchisio-Pjanic, with Lemina-Biglia or Gustavo-Asamoah as backups. Looks strong to me.
We need to offload Pereyra and Hernanes, and perhaps Sturaro too (though I think we'll keep him). We'll keep Mandragora until January I think.
Mandragora looks promising and I'd give him a try in some serie A games until Marchisio comes back but he's still injured too, so we can forget about that. Hence, we need a DM.