His big mistake vs Lyon away was starting a very soft midfield and playing Dybala at false 9. Now don't get me wrong Dybala is awesome, but when you are playing a midfield that poses 0 goal scoring threat and is completely lacking in it's ability to impose itself on the game, then you don't start a false 9. We had literally 0 presence within the box almost the entire game. However, once Pjanic+Rabiot came off and Ramsey+Higuain came on, the difference was clear as day. We dominated from tat point forward and actually managed to create some clear cut opportunities.
I would personally go with the same starting XI that we saw against Inter. Dybala is a key player for this team; however, I just feel as though he won't be as useful as Higuain against a team which bunkers down. Bringing on Dybala whilst hopefully being ahead on aggregate in the second half will be very effective. Just as on Sunday he would will bring that needed spark and will have the ability to out run defenders due to their tired legs.