Probably, delneris 442 could work better than current strange tactics we are using.
Del Neri would be playing like
Tek
Rugani Danilo Bonucci Gatti
Chiesa Paredes Locatelli Rabiot
Di Maria Vlahovic
We'd have Chiesa (Krasic) as our only reliable source of offense, and otherwise hoping Di Maria (Del Piero) can come up with something, or to link up with Vlahovic (Quag first half, Matri second or even Toni). Those Chiesa and Vlahovic are probably an upgrade but tbh apart from that it's about the same standard of squad atm*. He'd be playing Rugani (il nuovo sorensen) at RB and our biggest CB at LB (like Chiellini) and basically the most boring set of players ever in the middle of the pitch not doing much of anything.
I can't even remember who played at CB with Bonucci that year while Chiellini was at LB.
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McKennie would have been the perfect Pepe stand-in on the left wing, but he's gone, we've not even got Pepe anymore ffs
*edit: barring the young players coming through, some of which I think are really exciting. Fagioli is Marchisio, Iling Junior is Giovinco and Miretti is a spare