Again it's not a symmetric 433.more of a 4321.
As a 4-3-3 that probably wouldn't work, but with as a 4-3-2-1 with Dybala playing more centrally from the left, and Cuadrado giving some width and overloading the right it might work quite well.
I see us playing a 4-3-1-2 though, as I really don't see the point of the Hernanes purchase otherwise. I highly doubt we brought him to be a CM, as we also bought Lemina for that. And if we're playing a 3 man midfield in a 4-3-3 that leaves us with Pogba, Marchisio, Lemina, Sturaro, Pereyra, Khedira, Asamoah, Padoin, Hernanes to fit into the rotation. That's 9 players for CM. That would be crazy. If we're playing a 4 man midfield with a CAM, it makes much more sense. Hernanes, Pereyra and Cuadrado can all play CAM, and then we have 6 players left over for the three other midfield spots. Cuadrado's versatility is really quite fantastic as he played RWF, RWB, RCM, SS, and AM for Fiorentina at times. He's actually quite a decent SS and AM, even if his best position is RWF.
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I remember @DAiDEViL suggested this :
Buffon
Licht-Bonucci-Chiellini-Sandro
Marchisio
Hernanes------Pogba
Pereyra
Dybala-Morata
I'd like this lineup especially in CL when we look to hit teams on the break.
Replace Hernanes with Asamoah if he returns from his injury and to top form again. Big if, but I think he might be a game-changer for us in Midfield if it happens.