What happens if Dybala and/or Cuadrado are injured or suspended? Last time I checked, we only have 4 strikers and 0 options on the wings besides those 2 (if you can even consider Dybala a winger) to play 4-3-3. We used to have this guy called Coman. Oh yeah. He could play on the wing and offer some quantity as well as quality in attack. Where is he now?!
Morata is actually quite decent as a LWF. Some of his best performances for Madrid came in that position. However, I really don't see us playing 4-3-3 often, as if we had planned on it, there's absolutely no way we would have sold COman. We would have made it clear to him that we were going to be playing a formation where he would get much more game time.
Aside from this. Dybala plays more on the right as he likes to cut in and shoot with his left. If he was put on the wing that would be the side to go. But since we have Cuadrado for that, it would be pointless. I think a front 2 is best with Morata and Dybala ahead of Hernanes. Or even a 4-3-2-1 with Dybala-Cuadrado behind Morata. Cuadrado played decently as an SS for the Viola when asked.
A 4-3-1-2 though:
Buffon
Licht-Bonucci-Chiellini-Sandro
Cuadrado-Marchisio-Pogba
Hernanes
Dybala-Morata
Would be a very good attacking team imo. Replace Cuadrado with Sturaro, and Hernanes with Pereyra for a little more steel in the midfield dependent on the opponent. And we'll see how Khedira and Asamoah slot in when they return. Asamoah-Marchisio-Pogba might end up being our best midfield in the end. Although it's hard to say if Asamoah works at RCM, or should be playing where Pogba is at LCM.