They will lose ALOT, Balotelli I prolly rate more then several of you, but Milito in pure gameplay wise have been hugely important in helping out their uncreative midfield (Eto'o is a ghost in comparison), assisting, linking up, not to mention scoring all goals for them. I have genuinly been very impressed with him.
Balotelli is still very inconsistent in his age, extremely so, despite his talents, and cant really cover for Milito with how productive he has been.
Missing Milito for Inter is a huge blow.