At this point Matuidi or Witsel wouldn't be the end of the world.
Key CMs - 1) Khedira, 2) Marchisio, 3) Pjanic, 4) Matuidi/Witsel, 5) Asamoah, 6) Lemina + Sturaro & Mandragora (who both wouldn't make the UCL cut).
That should be good for 3 positions in midfield especially since the first 4 have adequate experience and dependability with their respective national teams / UCL.
Having Cuadrado as someone said above, also gives us the option to revert to different systems if we face a CM injury crisis that compromises the quality of the overall mids.