Play 3-5-2. Man-mark the shit out of Barella. Put Chiellini on Lukaku; he can still get yellow-carded and is easily provoked.
I'd allow them a bit more possession like against Roma, because we have such fantastic players on the counter (Ronaldo, Cuadrado, Kulu, Morata, Chiesa) and Inter are bound to open gaps when they are forced to play offensive defenders like Hakimi high up to try and open the unlock our defense. This means we have to play our A-tier defenders though, and it comes with a risk.