I doubt it will be radically new. They'll basically have taken CM 4, debugged it using their fantastic Beta testing method of releasing it to an unsuspecting public and using the money and complaints of errors so generated, and updated the squad lists and player stats.
I don't expect anything radically new about it. Oh, I've head that they've put the "past games" against your next opponent button back in. (Yay!)
BTW, thanks GOAT.