Starting to look that way, indeed - would be hard to trust even if he plays, potentially being little more than a decoy. From your backups, I still think matthews would be the most solid choice, followed by Bryant and Moncrief, both of whom are hard to trust, boom-or-bust plays. If Reggie Wayne is out and if your opponent has a high scoring team, Moncrief may well be someone worth taking a chance on, imo, even more so than Bryant.
Wouldn't expect much from Landry this week as he'd likely draw Revis.
Might also wanna consider using Orten over Tannehill - it's a bit of a wash but in cases like these, I'd go with the home-field play. Tannehill has had a very good year so far but would be very surprised if he produces much this week (an away divisional game, in December, vs a good Pats secondary).
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@AFL_ITALIA
If the guy you are playing has a free-scoring team and it seems he does, considering you were a 15pt or so underdog even with Julio Jones as a starter, you may even consider sitting Floyd and starting Matthews and Moncrief (again, provided Wayne sits out this game, which would make Moncrief a viable play). Floyd is very much a matchup-proof WR3/flex with a relatively high floor but low ceiling too. I recommended him to you earlier when you needed solid production in a match-up where you were the projected favorite but this seems like a different situation now, where you may have to take a chance or two in order to have a shot at winning.
So, if Reggie Wayne is out, I think it would be worth going with Matthews and Moncrief in place of jones and floyd, considering your league opponent for the week.