Definitely hurts to be a 49ers fan. Two weeks in a row I couldn't even get to halftime. Disagree that it's because Harbaugh is gone, though. The environment was already toxic last year, and he wouldn't be able to fix things right now.
Almost all new coaches, though. That's a big problem. No more A. Davis, Iupati, Crab, Gore, V. Davis (for all intents and purposes), J. Smith, A.Smith, Willis, Borland, Culliver, etc... there are huge skill/leadership voids amongst the players.
Underwhelming Torrey Smith getting huge money, terrible Darnell Dockett 2M toilet flush -- free agency did not go well -- Boldin probably entering decline, no reprieve from Kaepernick regression, a couple of poor drafts catching up to the team, etc...
It looks bad all the way round, and doesn't resemble a quick fix. Going to be getting a high draft pick the next couple of seasons, IMO.