Dybala would obviously have to move towards the right wing more often. His game has to copy Messi in many ways - play-making, going between the lines, taking people 1vs1...
Having in mind that Gonzalo is much more of a poacher than Suarez, we need a serious left wing presence and I think Pjaca is ideal with his stamina and physique. That would allow Dybala even less defensive duties.
I think we are going for the 433 by next season. Might this limit Paulo - maybe, but if he is half as great as we hope he is, he would not only adapt but thrive in it. When I see Gonzalo behind Dybala trying to be the creator its a little bit better than watching Trezeguet trying to create for ADP, but overall the same feeling.