It's 5hrs and 18 min with toll and there's a ca 10 mile difference between the two. I don't know exactly how much the toll is in total but I would put my guess at around $10-15. It's not much but if you can go another 40 min and not pay a toll it's not so bad
A full tank of gas in my Accord should do it (ca $30). The mileage isn't all that bad it's just that some of the roads we'll be taking have relatively low speed limits (mapquest.com takes that into account)