I don't think we should continue playing a 4-4-2 unless we are getting Ribery, Silva, or even Bastos. Obviously if this happens, it would imply no Diego, and potentially limited opportunities for Giovinco. In addition, we would also be required to buy a competent RM to compensate for Camo's constant injuries and Macro Macaroni's incompetency.
Ideally we should sell:
Molinaro
Knezevic
Zebina
Tiago
Poulsen
Zanetti
Marchionni
Trezeguet
I would even add Grygera. However, we can realistically expect to get rid of Tiago Poulsen, Knezevic (loan return), and possibly Trezeguet (if he no longer wishes to remain here). Let us also not forget about Almiron, and Palladino.
I would acquire:
A decent RB
Recall Criscito from Genoa @ all costs
A CB whose name is not Fabio Cannelloni
Diego
Guberti
An up and coming striker whose name is not Cassano, Floccari, or Quagliarella
If we were to dispose of both Tiago and Poulsen, then we would obviously need a new CM, and Ekdal can also be promoted to the 1st team
With these acquisitions we can play 4-4-2, 4-3-2-1, and 4-3-1-2 with their variations
Here is what my my team would look like:
GKs:
Buffon
Manninger
GK 3
Defence:
Chiellini
Agger
Criscito
Mellberg
Legrottaglie
Decent RB
Molinaro
Grygera
Midfield:
Marchisio
Sissoko
Asamoah
Ekdal
Zanetti
Diego
Camoranesi
Guberti
De Ceglie
Attack:
Del Piero
Giovinco
Amauri
Iaquinta
Up and Coming striker