Serious question guys
In terms of
CM
CDM
LM
RM
LCM
RCM
What is mezzala and regista?
Mezzala (LCM, RCM?)
Regista (Deep Lying Midfielder CDM?)
Is both only used in 433 variations (4231, 4321 etc)?
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I'm an idiot so others can give better answers, but the way I see it is CM, LM etc etc are positions, and mezzala, regista, trequartista etc are more like roles.
These days especially it's impossible to convey a team's system with a 2D image showing positions on the pitch, every team is way more dynamic. A 2D image is only really meaningful when you understand something about the style of play of each individual, from which you can infer the type of role they'll be playing.
A regista is a deep-lying playmaker. The type of player who is available for a pass forward from the defence, or sideways or even backwards from the other midfielders, and who picks out attacking players with their passes forward either to the CFs or to wide players. The obvious player to point to with this role is Pirlo.
A mezzala is somebody who occupies the space between the DM (whether regista or more like a destroyer DM) and the attack, and who usually sticks to their side of the pitch but they aren't a winger, they stay towards the centre. Pogba in his last spell here is a great example of that role.
In a three-man midfield you could go with a regista and two mezzale, or a destroyer DM and two mezzale, but if the DM is more of a defender I'd want to include a box-to-box CM in the midfield 3. Our 352 under Conte had a regista, box-to-box and mezzala (Pirlo, Vidal and Pogba). Our Cardiff team had a central midfield two of a box-to-box and a regista (Khedira and Pjanic) - and it depends on the squad available to the manager and their tactical tendencies how they want to set up the team, but you'd expect the midfield to be central to the overall tactical approach because obviously it occupies the space between defence and attack.
That's my understanding, anyway.
Edit: going by the position abbreviations you gave - for example an RCM could be a box-to-box or a mezzala, it depends on the system and the player. DM could be a destroyer or a regista.