Do you mean in terms of resting some players? In any case I think Trezeguet should be benched, it seems he is under too much pressure (from himself). With some rest he will be back banging goals.
Tiago should also play 90 minutes, this is the only way he can get on form.
I would also move Salihamidzic to the RB and Grygera to LB if Zebina is not in full form.
I would like to see something like this
Buffon
Salihamidzic Stendardo Chiellini Grygera
Sissoko
Camoranesi Tiago Palladino
Iaquinta Del Piero