This is also a tough game for the 3-5-2.
Playing against 4-3-3 is always awkward as you have to find the balance between not leaving your back three playing three-on-three with the opposition forwards and avoiding your wingbacks getting stuck deep and being deprived of any width higher up the pitch.
With Totti's inclination to drop deep and make Roma's 4-3-3 play more like 4-3-1-2 at times, it may be a good game to play Pogba and make use of his superior defensive abilities (compared to Pirlo) so that he can play Totti whenever he drops deep, so as to avoid the defence being three-on-three or one of the CBs being dragged out of position by Totti.
Juve will also have to watch for Roma's runners coming from deep in midfield - as Florenzi did for his goal against Inter - and that is something Pirlo is not good at and is a well known weakness of teams with Pirlo in them.
However, I wouldn't expect Roma to try and man-mark Pirlo, so there would be every chance he could be very influential if he did play.
Decisions, decisions...