Considering we have Inter on Saturday and Nordsjaelland on Wednesday...it may be wise to carry out some sort of rotation, something like below:
-----------------------Buffon--------------
-----Lucio-------Bonucci--------Caceres----
Isla--------------------------------------De Ceglie
------Pogba------Marrone/Pirlo------Giaccherini----
-------------Quagliarella------Matri----------