It would be interesting to see but i think Pep wouldnt want to sacrifice having 3 CMs and 2 wings on the pitch, so probably a defender gets left out. maybe a very offensive high pressing 352 with Ronaldo-Dybala? Pogba and SMS arent known as fast and hardworking mids (youll often find them being called lazy), but in tight spaces they can break up attacks due to their length and limited space they have to cover fairly well. But for this to work youd need an Emre Can on steroids behind them, and 2 high workrate wings that will sprint back to prevent easy counters (Costa, Chiesa, Cancelo would be these i guess, Berna isnt really fast). AS would be the odd man out here in that case (or Chiellini, with AS at LCB Alaba style). Defending set pieces? Pogba, SMS, 2-3 CBs, Can, CR. It could work