He played as a RW for Argentina and it was a failed experiment. Sampaoli most likely wont take him to the WC because of it. He's best in the cente of the field in a free role imo.
We need a hybrid CM-winger a la Koke or Saul to make the 442 work with Pjanic - Khedira/Matuidi.
I don't even think Pjanic is suited for this formation at all.
I think the only midfielder or striker that actually fits this formation is Cuadrado who is a traditional 4-4-2 style winger. Matuidi mayyyyyybe fits it but you want a little more overall technique from the CM.
You basically need two immense CMs. Like a Saul-Kante partnership or Vidal-Verratti.
For me, all our formation options come down to how can you inconvenience everyone the least. Because no matter what, someone is playing in a position not designed for them.
As far as Dybala goes, he looks bad at RW for Argentina I agree. But he has basically no minutes there in his career. With us, I think we could have given him a run against the minnows of Serie A just to see.
Because right now with him in the centre we are basically sacrificing a DM to protect our CBs and allowing teams huge spaces between the lines because we only have 2 CMs. If he played RW, you would sacrifice his side of the pitch, but at least it's not the fucking centre of the field, right on top of the box.