Pjaca instead of Mandzukic means marchisio rincon midfield and pjanic benched
Like sergio said, the beautiful thing about this formation, is that we are still discovering what we can do and what we cannot.
On paper, yes, it makes sense that to use pjaca on the wing, we would need 2 more physical players as dms, but we are theorycrafting and this formation with pjanic and pjaca could pretty much work if pjaca gets the hang of what allegri wants from him defensively.
If he learns how to do this, we could easily play pjanic behind him and see to which extend we can field offensive players.
Nothing is written in stone right now. For the time being, mandzu is working good on that wing, but it doesnt mean his game there doesnt have shortcomings. So we can still experiment even more
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And yes, cuads should be the one getting subbed instead of mandz in our current experience with the formation.